Proresorptive actions of FSH and bone loss.

  title={Proresorptive actions of FSH and bone loss.},
  author={M Shoaib Zaidi and Harry C. Blair and Jameel Z Iqbal and Ling Ling Zhu and T. Rajendra Kumar and Alberta Zambonin Zallone and Li Sun},
  journal={Annals of the New York Academy of Sciences},
We review studies that propose follicle-stimulating hormone (FSH) as a physiologic stimulator of osteoclastic bone resorption. We hypothesize that, in addition to low estrogen, a rising FSH contributes to the increased bone resorption and bone loss in hypergonadism. This is of particular relevance to the perimenopausal transition, wherein profound bone loss is accompanied by trabecular perforations in the face of high FSH and normal estrogen levels. Potential therapeutic implications include… CONTINUE READING