Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway.

@article{Liu2011ProreninIV,
  title={Prorenin induces vascular smooth muscle cell proliferation and hypertrophy via epidermal growth factor receptor-mediated extracellular signal-regulated kinase and Akt activation pathway.},
  author={Gang Liu and Hirofumi Hitomi and Naohisa Hosomi and Yuki Shibayama and Daisuke Nakano and Hideyasu Kiyomoto and Hong Ma and Yasuyoshi Yamaji and Masakazu Kohno and Atsuhiro Ichihara and Hiroshi Itoh and Akira Nishiyama},
  journal={Journal of hypertension},
  year={2011},
  volume={29 4},
  pages={696-705}
}
BACKGROUND It is widely acknowledged that the (pro)renin receptor mediates angiotensin (Ang) II-dependent and Ang II-independent effects of prorenin. METHOD We examined the effect of prorenin on vascular smooth muscle cell (VSMC) signal transduction, proliferation, and hypertrophy. RESULTS Recombinant rat prorenin dose-dependently increased extracellular signal-regulated kinase (ERK) 1/2 and Akt phosphorylation in rat VSMCs. Prorenin also significantly increased cell number, and [H… CONTINUE READING
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