Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren.

@article{Schefe2008ProreninET,
  title={Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren.},
  author={Jan H. Schefe and Christian Neumann and Matthias Goebel and Jan A. H. Danser and Sebastian Marius Kirsch and Ronald Gust and Ulrich Kintscher and Thomas Unger and Heiko Funke-Kaiser},
  journal={Journal of hypertension},
  year={2008},
  volume={26 9},
  pages={1787-94}
}
OBJECTIVES Inhibition of (pro)renin receptor activation was demonstrated to inhibit or even abolish the development of end-organ damage in animal models. The new renin inhibitor, aliskiren, markedly increases the plasma concentration of the (pro)renin receptor ligands prorenin and renin in patients. The effects of prorenin and of renin inhibitors on the signal transduction cascade of the (pro)renin receptor are currently unknown. RESULTS Our results indicate that renin and prorenin were… CONTINUE READING

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