Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents.

@article{Nguyen2008ProreninA,
  title={Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents.},
  author={Genevi{\`e}ve Nguyen and A. H. Jan Danser},
  journal={Experimental physiology},
  year={2008},
  volume={93 5},
  pages={557-63}
}
The discovery of a (pro)renin receptor [(P)RR] and the introduction of renin inhibitors in the clinic have brought renin and prorenin back into the spotlight. The (P)RR binds both renin and its inactive precursor prorenin, and such binding triggers intracellular signalling that upregulates the expression of profibrotic genes, potentially leading to cardiac and renal fibrosis, growth and remodelling. Simultaneously, binding of renin to the (P)RR increases its angiotensin I-generating activity… CONTINUE READING

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Expression of (pro)renin receptor in mouse embryonic and newborn kidney and proliferative effect of soluble (P)RR on mesangial cells

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