Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice.


OBJECTIVE Administration of the handle region peptide (HRP), a (pro)renin receptor blocker, decreases body weight gain and visceral adipose tissue (VAT) in high-fat/high-carbohydrate (HF/HC) diet-fed mice. The objective of this study was to elucidate potential mechanisms implicated in these observations. METHODS Mice were given a normal or a HF/HC diet… (More)
DOI: 10.1002/oby.21592


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