Propylene glycol monomethyl ether (PGME): inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice.

@article{Spencer2002PropyleneGM,
  title={Propylene glycol monomethyl ether (PGME): inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice.},
  author={Pamela J. Spencer and James W Crissman and William T Stott and Richard A. Corley and Frank S Cieszlak and Alan M. Schumann and Jerry F. Hardisty},
  journal={Toxicologic pathology},
  year={2002},
  volume={30 5},
  pages={570-9}
}
A series of inhalation studies with propylene glycol monomethyl ether (PGME) vapor were undertaken to characterize its subchronic toxicity in mice and chronic toxicity/oncogenicity in rats and mice. Groups of male and female Fischer 344 rats and B6C3F1 mice were exposed to 0, 300, 1,000, or 3,000 ppm vapor from 1 week to 2 years. Primary treatment-related effects included: initial sedation of animals exposed to 3,000 ppm and its subsequent resolution correlating with induction of hepatic mixed… CONTINUE READING
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