Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans

  title={Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans},
  author={P. Speth and T. Vree and N. F. Neilen and P. D. de Mulder and D. Newell and M. E. Gore and B. D. de Pauw},
  journal={Therapeutic Drug Monitoring},
  • P. Speth, T. Vree, +4 authors B. D. de Pauw
  • Published 1987
  • Chemistry, Medicine
  • Therapeutic Drug Monitoring
  • Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The… CONTINUE READING
    58 Citations
    Pharmacokinetics of propylene glycol after rectal administration
    • 8
    • Highly Influenced
    Propylene glycol toxicity in children.
    • 53
    A Prospective Evaluation of Propylene Glycol Clearance and Accumulation During Continuous-Infusion Lorazepam in Critically Ill Patients
    • 32
    Clinical pharmacology of propylene glycol in neonates
    • Highly Influenced
    • PDF
    Low but Inducible Contribution of Renal Elimination to Clearance of Propylene Glycol in Preterm and Term Neonates
    • 10
    Developmental pharmacokinetics of propylene glycol in preterm and term neonates.
    • 28
    Prospective assessment of short-term propylene glycol tolerance in neonates
    • 38