Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans

@article{Speth1987PropyleneGP,
  title={Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans},
  author={P. Speth and T. Vree and N. F. Neilen and P. D. de Mulder and D. Newell and M. E. Gore and B. D. de Pauw},
  journal={Therapeutic Drug Monitoring},
  year={1987},
  volume={9},
  pages={255–258}
}
  • P. Speth, T. Vree, +4 authors B. D. de Pauw
  • Published 1987
  • Chemistry, Medicine
  • Therapeutic Drug Monitoring
  • Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The… CONTINUE READING
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