Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans

@article{Speth1987PropyleneGP,
  title={Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans},
  author={Paul A. J. Speth and Tom B. Vree and N F Neilen and P H M de Mulder and David Richard Newell and Martin Eric Gore and Ben E. de Pauw},
  journal={Therapeutic Drug Monitoring},
  year={1987},
  volume={9},
  pages={255–258}
}
Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The… Expand
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A pharmacokinetic model was developed for PG co-administered with paracetamol or phenobarbital in neonates and shows that large variability in PG exposure may be expected in Neonates which is dependent on birth weight and age of the neonates. Expand
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