Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans
@article{Speth1987PropyleneGP, title={Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans}, author={P. Speth and T. Vree and N. F. Neilen and P. D. de Mulder and D. Newell and M. E. Gore and B. D. de Pauw}, journal={Therapeutic Drug Monitoring}, year={1987}, volume={9}, pages={255–258} }
Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The… CONTINUE READING
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