Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans

  title={Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans},
  author={Paul A. J. Speth and Tom B. Vree and N F Neilen and P H M de Mulder and David Richard Newell and Martin Eric Gore and Ben E. de Pauw},
  journal={Therapeutic Drug Monitoring},
Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The… Expand
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