• DOI:10.1097/00007691-198709000-00001
Corpus ID: 23317790

Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans

@article{Speth1987PropyleneGP,
  title={Propylene Glycol Pharmacokinetics and Effects after Intravenous Infusion in Humans},
  author={P. Speth and T. Vree and N. F. Neilen and P. D. de Mulder and D. Newell and M. E. Gore and B. D. de Pauw},
  journal={Therapeutic Drug Monitoring},
  year={1987},
  volume={9},
  pages={255–258}
}

P. Speth, T. Vree, +4 authors B. D. de Pauw

Published 1987

Chemistry, Medicine

Therapeutic Drug Monitoring

Knowledge of the pharmacokinetics of propylene glycol (PG) is scarce, though it is used in a number of preparations for intravenous use. Although systemic toxicity appears to be uncommon, PG has been reported to cause lactic acidosis and other adverse effects. We describe a rapid gas chromatographic assay method for PG and the plasma pharmacokinetics after intravenous administration to six patients on nine occasions. The pharmacokinetics were nonlinear, based on a saturable clearance. The… CONTINUE READING

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