Proprotein convertase activation of aggrecanases in cartilage in situ.

  title={Proprotein convertase activation of aggrecanases in cartilage in situ.},
  author={A M Malfait and Elizabeth C. Arner and Ruo-Hua Song and James T. Alston and Stella Markosyan and Nicholas R Staten and Zhiyong Yang and David W. Griggs and Micky D. Tortorella},
  journal={Archives of biochemistry and biophysics},
  volume={478 1},
Proteolytic degradation of the major cartilage macromolecules, aggrecan and type II collagen, is a key pathological event in osteoarthritis (OA). ADAMTS-4 and ADAMTS-5, the primary aggrecanases capable of cartilage aggrecan cleavage, are synthesized as latent enzymes and require prodomain removal for activity. The N-termini of the mature proteases suggest that activation involves a proprotein convertase, but the specific family member responsible for aggrecanase activation in cartilage in situ… CONTINUE READING

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