Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition.

@article{Cottrill1977PropranololTD,
  title={Propranolol therapy during pregnancy, labor, and delivery: evidence for transplacental drug transfer and impaired neonatal drug disposition.},
  author={Carol M. Cottrill and Russell G Mcallister and Leonard S. Gettes and Jacqueline Anne Noonan},
  journal={The Journal of pediatrics},
  year={1977},
  volume={91 5},
  pages={
          812-4
        }
}
The administration of 160 mg of propranolol during pregnancy, labor, and delivery was associated with profound hypoglycemia and respiratory depression in a newborn infant. The neonate's plasma propranolol level rose from 40 ng/ml at the time of birth to 90 ng/ml four hours later. This increase in plasma propranolol concentration might be due to redistribution of the drug in the neonate as well as to different elimination mechanisms than in adults. The elevated propranolol level four hours after… CONTINUE READING