Propranolol targets the contractility of infantile haemangioma-derived pericytes.

  title={Propranolol targets the contractility of infantile haemangioma-derived pericytes.},
  author={Donna Dong-Young Lee and Elisa Boscolo and Jennifer T. Durham and John Butler Mulliken and Ira M. Herman and Joyce Bischoff},
  journal={The British journal of dermatology},
  volume={171 5},
BACKGROUND Propranolol, a β-adrenergic receptor (AR) antagonist, is an effective treatment for endangering infantile haemangioma (IH). Dramatic fading of cutaneous colour is often seen a short time after initiating propranolol therapy, with accelerated regression of IH blood vessels discerned after weeks to months. OBJECTIVES To assess a possible role for haemangioma-derived pericytes (HemPericytes) isolated from proliferating and involuting phase tumours in apparent propranolol-induced… CONTINUE READING
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