Propranolol stimulates histone phosphorylation by a putative PK-C in partially purified homogenate of rat testicular interstitial cells. A possible mechanism for increased testosterone secretion by propranolol.

Abstract

The beta-adrenoceptor blocker propranolol stimulated testosterone secretion by rat testicular interstitial cells (Leydig cell-enriched preparation) in vitro at concentrations ranging from 10(-5) M to 10(-4) M. Treatment of these cells with H7 (20 microM), an inhibitor of protein kinase C, reduced the stimulatory effect of L-propranolol on testosterone… (More)

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@article{Wanderley2000PropranololSH, title={Propranolol stimulates histone phosphorylation by a putative PK-C in partially purified homogenate of rat testicular interstitial cells. A possible mechanism for increased testosterone secretion by propranolol.}, author={Miguel Wanderley and Daniel Pedro Udrisar and M. C. Martins and Jos{\'e} Antunes-Rodrigues}, journal={Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme}, year={2000}, volume={32 7}, pages={259-64} }