Propranolol induces contractions of canine small and large coronary arteries

  title={Propranolol induces contractions of canine small and large coronary arteries},
  author={P D Turlapaty and Burton M. Altura},
  journal={Basic Research in Cardiology},
SummaryUsing isolated canine small (right coronary branch, left coronary branch; o. d. 0.4–0.8 mm) and large (left coronary, circumflex; o. d. 1–2 mm) coronary arteries, thebeta-adrenergic antagonist dl-propranolol (5×10−7 to 5×10−5 m/l) was found to produce concentration-dependent contractions. Interestingly, most of these contractile events take place with concentrations of propranolol (0.1–1 μg/ml) found in the blood of patients who are taking this drug for various therapeutic reasons. These… 
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