Propranolol enhances the effect of ACTH on plasma cortisol, but not on aldosterone in man

@article{Belkien1983PropranololET,
  title={Propranolol enhances the effect of ACTH on plasma cortisol, but not on aldosterone in man},
  author={L. Belkien and Joachim Baumann and M Schirpai and W. Oelkers},
  journal={Journal of Endocrinological Investigation},
  year={1983},
  volume={6},
  pages={341-345}
}
An accidental observation led to the suspicion that propranolol (P) enhances the effect of exogenous ACTH on plasma cortisol. To examine this matter further, large-dose ACTH tests (25 IU im) were performed in 10 normal young males: i) without treatment (n = 10); ii) after 1 1/2 days of P treatment (n = 10); iii) after 1 1/2 days of metoprolol treatment (n = 6). Six other subjects received infusions of 0.2 IU of ACTH/hour for 12 h: i) without pretreatment; ii) after 1 1/2 days of P treatment. P… 

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SUMMARY

References

SHOWING 1-10 OF 16 REFERENCES

Effects of propranolol on aldosterone plasma concentration and aldosterone metabolic clearance in hypertensive patients.

Propranolol administered to hypertensive patients pretreated with a diuretic can affect circulating levels of aldosterone apart from changes in PRA.

Effect of propranolol therapy on aldosterone responses to angiotensin II and adrenocorticotropic hormone in essential hypertension.

It is concluded that changes in adrenal sensitivity are not responsible for maintaining unchanged supine plasma aldosterone concentrations after beta-adrenoceptor antagonism in essential hypertension.

Studies on the mechanism by which ACTH stimulates renin activity and angiotensin II formation in man.

The conclusion is made that the effect of ACTH on PRA and P-A II is not mediated by renal beta-adrenergic receptors, but perhaps (partially?) by prostaglandins.

Corticotrophin stimulation test: inverse correlation between basal serum cortisol and its response to corticotrophin.

Inverse correlation between basal serum cortisol and the increase in serum cortisol suggests that in patients who have high basal cortisol levels, endogenous ACTH may already have reduced the cortisol reserve of the adrenal gland.

The effect of ACTH and cortisol on aldosterone and cortisol clearance and distribution in plasma and whole blood.

The results suggest that a fraction of aldosterone is bound in plasma and displaced by cortisol into red cells, which results from both an increased splanchnic extraction as plasma binding sites approach saturation and a redistribution intored cells.

Effects of progesterone and four synthetic progestagens on sodium balance and the renin-aldosterone system in man.

The influence of treatment with progesterone and with 4 synthetic progestagens for 6 days on sodium balance and on different factors of the renin-aldosterone system was investigated in 20 young healthy men on a fixed sodium intake.

Changes in plasma levels of 17-hydroxycorticosteroids during the intravenous administration of adrenocorticotropin (ACTH). IV. Response to prolonged infusions of small amounts of ACTH.

In males the maximal plasma 17-hydroxycorticosteroid levels can probably be achieved during the normal diurnal variation by the secretion of ACTH at a rate of less than 4 i.u. per day.

Adrenocorticotropin-stimulated secretion of aldosterone and cortisol, computed from plasma and red blood cell measurements.

The dynamic response of the adrenal cortex to ACTH infusion is analyzed by simulating the distribution, binding, and metabolism of cortisol and aldosterone in a multicompartmental model. The model