Propranolol enhances the effect of ACTH on plasma cortisol, but not on aldosterone in man

  title={Propranolol enhances the effect of ACTH on plasma cortisol, but not on aldosterone in man},
  author={L. Belkien and Joachim Baumann and M Schirpai and W. Oelkers},
  journal={Journal of Endocrinological Investigation},
An accidental observation led to the suspicion that propranolol (P) enhances the effect of exogenous ACTH on plasma cortisol. To examine this matter further, large-dose ACTH tests (25 IU im) were performed in 10 normal young males: i) without treatment (n = 10); ii) after 1 1/2 days of P treatment (n = 10); iii) after 1 1/2 days of metoprolol treatment (n = 6). Six other subjects received infusions of 0.2 IU of ACTH/hour for 12 h: i) without pretreatment; ii) after 1 1/2 days of P treatment. P… 

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Propranolol administered to hypertensive patients pretreated with a diuretic can affect circulating levels of aldosterone apart from changes in PRA.

Effect of propranolol therapy on aldosterone responses to angiotensin II and adrenocorticotropic hormone in essential hypertension.

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