Propranolol compared with propranolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis. A randomized controlled study.

Abstract

OBJECTIVE To investigate whether isosorbide-5-mononitrate (Is-5-Mn) given with propranolol reduces hepatic portal pressure more than does propranolol alone in patients with cirrhosis. DESIGN A randomized controlled trial. PATIENTS Fifty patients with cirrhosis and esophageal varices entered and 42 completed the study. INTERVENTION Twenty-one patients… (More)

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