Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis.

@article{Wang2005PropranololAA,
  title={Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis.},
  author={J F Wang and Achim Meissner and Sohail Malek and Yan Chen and Qingen Ke and Jielin Zhang and Victor P. Chu and Thomas G. Hampton and Clyde S. Crumpacker and Walter H. Abelmann and Ivo Amende and James Plunkett Morgan},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 4},
  pages={H1577-83}
}
Recent studies point to important interactions between proinflammatory cytokines and neurohumoral mediators in heart failure. Here we investigate the influence of the beta-adrenergic system on cytokines and neurohumoral factors and the sequelae of viral myocarditis. In an experimental model with virus-infected BALB/c mice, we studied the acute and chronic effects of epinephrine and propranolol on myocardial morphology, cytokine gene expression, and survival. BALB/c mice were inoculated with the… CONTINUE READING

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