Propranolol: pooled Michaelis-Menten parameters and the effect of input rate on bioavailability.

  • John E Wagner
  • Published 1985 in Clinical pharmacology and therapeutics


Average steady-state propranolol plasma concentration (Css) were calculated from published steady-state propranolol clearance data for dose rates (Ro) of 40, 80, 160, 240, and 320 mg/ day in divided doses every 6 hours. The Css-Ro data for each of four subjects were fit essentially perfectly by the equation: Css = KmRo/ (Vm-Ro). Very similar Vm and Km… (More)