Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient.

  title={Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient.},
  author={T. P. Gibson and Kathleen M. Giacomini and William A. Briggs and W Whitman and Gerhard Levy},
  journal={Clinical pharmacology and therapeutics},
  volume={27 5},
The widely used analgesic propoxyphene is subject to extensive presystemic (first-pass) biotransformation after oral administration. There have been indications that presystemic biotransformation of a drug may be less in anephric patients than in healthy subjects. Plasma concentrations of propoxyphene (a drug with dangerous adverse effects at high concentrations) and its major and pharmacologically active metabolite norpropoxyphene have been compared in 7 anephric patients and 7 healthy… CONTINUE READING


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