Proposed strategy for optimizing aldosterone blockade in heart failure.

@article{Jolobe2012ProposedSF,
  title={Proposed strategy for optimizing aldosterone blockade in heart failure.},
  author={O M P Jolobe},
  journal={American heart journal},
  year={2012},
  volume={164 2},
  pages={e1; author reply e3}
}
After the documentation of increased risk ofworsening of congestive heart failure (CHF) and worsening of renal function (WRF) in older patients with heart failure coprescribed frusemide and spironolactone while receiving an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker therapy, downward titration of loop diuretic dosage should be the new strategy for optimizing the survival benefit inherent in the use of spironolactone. The aim would be to neutralize, at least in… CONTINUE READING