Proposed Mechanism of Nitrite-Induced Methemoglobinemia

@article{Titov2005ProposedMO,
  title={Proposed Mechanism of Nitrite-Induced Methemoglobinemia},
  author={Vladimir Titov and Yu. M. Petrenko},
  journal={Biochemistry (Moscow)},
  year={2005},
  volume={70},
  pages={473-483}
}
A scheme of development of nitrite-induced oxyhemoglobin oxidation in erythrocytes based on the analysis of experimental data is proposed. It was found that, contrary to widespread opinion, direct oxidative-reductive interaction between hemoglobin and nitrite is absent or negligible under physiological conditions. The driving stage of this process is methemoglobin-catalyzed peroxidase oxidation of nitrite. The product of the oxidation (presumably NO2·) directly oxidizes oxyhemoglobin to… 

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