Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group

  title={Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group},
  author={John M. Bennett and Daniel Catovsky and Marie‐Theregse Daniel and Georges Flandrin and D. A. G. Galton and H. R. Gralnick and Claude Sultan},
  journal={British Journal of Haematology},
A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a reference standard when newly developed cell-surface markers believed to characterize specific cell types are applied to cases of acute leukaemia. [] Key Method Proposals based on conventional morphological and cytochemical methods are offered following the study of peripheral blood and bone-marrow…

Classification of acute leukaemias.


It seems, therefore, that L2 may not only be a distinct variant within the ‘lymphoid’ group, but also one with a poorer outlook to successful treatment, and the survival data even in the L1 group are inferior to the results reported by some of the best centres for leukaemia therapy.

Current concerns in haematology. 2: Classification of acute leukaemia.

An alternative approach to the morphological classification of acute leukaemia that emphasises the number of lineages involved and the degree of maturation of leukaemic cells has been proposed.

Evolution of the French-American-British (FAB) proposals. Is there a place for acute basophilic leukemia?

  • F. Dick
  • Medicine
    American journal of clinical pathology
  • 1991
In 1976 when the French-American-British (FAB) proposals were first published, categorization of acute leukemia seemed simple. This disease was diagnosed and subclassified based primarily on Wright's

Classification of acute leukaemia: the need to incorporate cytogenetic and molecular genetic information.

  • B. Bain
  • Biology, Medicine
    Journal of clinical pathology
  • 1998
The European Group for the Immunological Classification of Leukemias (EGIL) has proposed that acute leukaemia be classified on the basis of immunophenotype alone, a morphological, immunological, cytogenetic (MIC) classification, which has the strength that it suggests standardised criteria for defining aLeukaemia as myeloid, T lineage, B lineage, or biphenotypic.


  • J. Godyn
  • Medicine
    British journal of haematology
  • 1988
The FAB classification system proposed in 1981 and the CCSG system of using FAB criteria are two different classification systems of ALL and their results are not compatible.

Lineage specific classification of leukaemia: results of the analysis of sixty cases of childhood leukaemia

Summary. In addition to conventional morphological, histochemical and immunological marker studies, cells from 60 children with leukaemia were further analysed using the Southern blot hybridization


Classification of the Acute Leukaemias

A working numerical notation has been devised for the cytomorphological classification of 238 cases of acute leukaemia in adults (20 years and above) admitted by the referring centres in the United