Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group

  title={Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group},
  author={John M. Bennett and Daniel Catovsky and Marie‐Theregse Daniel and Georges Flandrin and D. A. G. Galton and H. R. Gralnick and C. Sultan},
  journal={British Journal of Haematology},
A uniform system of classification and nomenclature of the acute leukaemias, at present lacking, should permit more accurate recording of the distribution of cases entered into clinical trials, and could provide a reference standard when newly developed cell-surface markers believed to characterize specific cell types are applied to cases of acute leukaemia. [...] Key Method Proposals based on conventional morphological and cytochemical methods are offered following the study of peripheral blood and bone-marrow…Expand
The FAB classification for acute myeloid leukaemia--is it outdated?
The FAB group felt that discrimination of myeloblasts from lymphoblasts on morphological characteristics only was insufficient, so they proposed to define the difference between acute myeloid leukaemia @ML) and acute lymphoblasticLeukaemia (ALL) by the positivity or negativity respectively of the blasts for the myeloperoxidase (MPO) or Sudan B Black reaction. Expand
Classification of acute leukaemias.
A simplified classification into broad groups is proposed, ALL being divided by surface antigenic and cytogenetic criteria and AML by morphology and cytochemistry, and the development and complexity of combined classifications which attempt to incorporate most of these features is illustrated. Expand
It seems, therefore, that L2 may not only be a distinct variant within the ‘lymphoid’ group, but also one with a poorer outlook to successful treatment, and the survival data even in the L1 group are inferior to the results reported by some of the best centres for leukaemia therapy. Expand
Acute lymphoblastic leukaemia in adults: clinicopathological correlations with the French-American-British (FAB) co-operative group classification.
A significant relationship was found between Burkitt-like cytology, (FAB) L 3 and Central Nervous System (CNS) disease at clinical and haematological remission and the incidence of primary CNS relapse was significantly greater in the FAB, L 1 group than L 2. Expand
Current concerns in haematology. 2: Classification of acute leukaemia.
An alternative approach to the morphological classification of acute leukaemia that emphasises the number of lineages involved and the degree of maturation of leukaemic cells has been proposed. Expand
Morphology of leukaemias
In 1976, the consensus that led to the French-American-British (FAB) classification was achieved and today, despite new classifications based on sophisticated studies, FAB classification is widely used by experts due to its technical simplicity, good diagnostic reliability and cost-effectiveness. Expand
Classification of acute leukaemia: the need to incorporate cytogenetic and molecular genetic information.
  • B. Bain
  • Medicine
  • Journal of clinical pathology
  • 1998
The European Group for the Immunological Classification of Leukemias (EGIL) has proposed that acute leukaemia be classified on the basis of immunophenotype alone, a morphological, immunological, cytogenetic (MIC) classification, which has the strength that it suggests standardised criteria for defining aLeukaemia as myeloid, T lineage, B lineage, or biphenotypic. Expand
  • J. Godyn
  • Medicine
  • British journal of haematology
  • 1988
The FAB classification system proposed in 1981 and the CCSG system of using FAB criteria are two different classification systems of ALL and their results are not compatible. Expand
Lineage specific classification of leukaemia: results of the analysis of sixty cases of childhood leukaemia
Summary. In addition to conventional morphological, histochemical and immunological marker studies, cells from 60 children with leukaemia were further analysed using the Southern blot hybridizationExpand
importance . leukaemia and its clinical childhood lymphoblastic morphological classification of French American British ( FAB )
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panelExpand


Classification of the Acute Leukaemias
A working numerical notation has been devised for the cytomorphological classification of 238 cases of acute leukaemia in adults (20 years and above) admitted by the referring centres in the UnitedExpand