Proportionally more deleterious genetic variation in European than in African populations.

  title={Proportionally more deleterious genetic variation in European than in African populations.},
  author={Kirk E. Lohmueller and Amit R. Indap and Steffen Schmidt and Adam R. Boyko and Ryan D. Hernandez and Melissa J. Hubisz and John Sninsky and Thomas J. White and Shamil R. Sunyaev and R. Nielsen and Andrew G. Clark and Carlos Daniel Bustamante},
  volume={451 7181},
Quantifying the number of deleterious mutations per diploid human genome is of crucial concern to both evolutionary and medical geneticists. Here we combine genome-wide polymorphism data from PCR-based exon resequencing, comparative genomic data across mammalian species, and protein structure predictions to estimate the number of functionally consequential single-nucleotide polymorphisms (SNPs) carried by each of 15 African American (AA) and 20 European American (EA) individuals. We find that… CONTINUE READING
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