Proportion of antigenic variants induced by in vitro UV irradiation differs in clones derived from a single tumor.

@article{Hostetler1988ProportionOA,
  title={Proportion of antigenic variants induced by in vitro UV irradiation differs in clones derived from a single tumor.},
  author={Laura Hostetler and Margaret L. Kripke},
  journal={Journal of immunology},
  year={1988},
  volume={140 2},
  pages={666-70}
}
The purpose of this study was to examine the capacity of different clones derived from the same tumor to generate highly antigenic cells after in vitro exposure to UV radiation. Cells from the metastatic murine melanoma K1735 and clones of K1735 differing in metastatic potential were exposed to UV radiation in vitro, cloned, and tested for antigenic properties in vivo. Approximately half of the clones isolated after UV irradiation of parental K1735 melanoma cells were highly antigenic (five of… CONTINUE READING

From This Paper

Topics from this paper.