Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride

@article{Bhadauria2007PropolisPC,
  title={Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride},
  author={Monika Bhadauria and Satendra Kumar Nirala and Sangeeta Shukla},
  journal={Molecular and Cellular Biochemistry},
  year={2007},
  volume={302},
  pages={215-224}
}
Induction of CYP 2E1 by carbon tetrachloride (CCl4) is one of the central pathways by which CCl4 generates oxidative stress in hepatocytes. Experimental liver injury was induced in rats by CCl4 to determine toxicological actions on CYP 2E1 by microsomal drug metabolizing enzymes. In this report, ethanolic extract of propolis at a dose of 200 mg/kg (po) was… CONTINUE READING