Propofol with N-acetylcysteine reduces global myocardial ischemic reperfusion injury more than ketamine in a rat model.

@article{Oksuz2009PropofolWN,
  title={Propofol with N-acetylcysteine reduces global myocardial ischemic reperfusion injury more than ketamine in a rat model.},
  author={Hafize Oksuz and Nimet Şenoğlu and Aptekin Yasim and Hasan Turut and Fatma Inanç Tolun and Harun Çiralik and Fidan Bilge},
  journal={Journal of investigative surgery : the official journal of the Academy of Surgical Research},
  year={2009},
  volume={22 5},
  pages={348-52}
}
OBJECTIVE We examined the cardioprotective effects of propofol and ketamine with and without N-acetylcysteine (NAC). METHODS 60 rats were divided into six groups of 10 rats each. Anesthesia induction was produced with an intraperitonal injection of ketamine in Groups 1-3 and propofol in Groups 4-6. NAC (200 mg kg(- 1)) was given intraperitonally during anesthesia induction in Groups 3 and 6. Groups 2, 3, 5, and 6 were subjected to 90 s of myocardial ischemia by clamping the ascending aorta… CONTINUE READING