Propofol produces immobility via action in the ventral horn of the spinal cord by a GABAergic mechanism.

@article{Kungys2009PropofolPI,
  title={Propofol produces immobility via action in the ventral horn of the spinal cord by a GABAergic mechanism.},
  author={Gudrun Kungys and Jongbun Kim and Steven L. Jinks and Richard J Atherley and Joseph Antognini},
  journal={Anesthesia and analgesia},
  year={2009},
  volume={108 5},
  pages={1531-7}
}
BACKGROUND We investigated the actions of propofol and isoflurane on nociceptive responses of neurons in the spinal cord. METHODS We determined nociceptive responses of lumbar neurons in the dorsal horn (<1200 microm) and ventral horn (>1200 microm) of decerebrate rats before and during propofol (1 effective dose, ED(50)) or isoflurane (1 minimum alveolar concentration) anesthesia. During recording of ventral horn neurons, we administered picrotoxin by infusion to determine whether isoflurane… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…