Propofol potentiates phenylephrine-induced contraction via cyclooxygenase inhibition in pulmonary artery smooth muscle.

@article{Ogawa2001PropofolPP,
  title={Propofol potentiates phenylephrine-induced contraction via cyclooxygenase inhibition in pulmonary artery smooth muscle.},
  author={Koji Ogawa and Satoru Tanaka and Paul A. Murray},
  journal={Anesthesiology},
  year={2001},
  volume={94 5},
  pages={833-9}
}
BACKGROUND The authors previously demonstrated in vivo that the pulmonary vasoconstrictor response to the a agonist phenylephrine is potentiated during propofol anesthesia compared with the conscious state. The current in vitro study tested the hypothesis that propofol potentiates phenylephrine-induced contraction by inhibiting the synthesis and/or activity of vasodilator metabolites of the cyclooxygenase pathway. METHODS Canine pulmonary arterial rings were suspended for isometric tension… CONTINUE READING