Propofol potentiates ATP-activated currents of recombinant P2X(4) receptor channels expressed in human embryonic kidney 293 cells.

@article{Tomioka2000PropofolPA,
  title={Propofol potentiates ATP-activated currents of recombinant P2X(4) receptor channels expressed in human embryonic kidney 293 cells.},
  author={Atsushi Tomioka and Shoogo Ueno and Keiko Kohama and Fumio Goto and Kinji Inoue},
  journal={Neuroscience letters},
  year={2000},
  volume={284 3},
  pages={167-70}
}
We examined the effects of a general anesthetic 2, 6-diisopropylphenol (propofol) on ATP- and alpha,beta-methylene ATP (alphabetameATP)-activated currents in the human embryonic kidney 293 (HEK 293) cells expressing recombinant P2X receptor channels, using the whole-cell patch-clamp method. Propofol at clinical relevant concentrations ( approximately 56 microM) potentiated the current responses through the P2X(4) receptor in a dose-dependent manner, whereas propofol did not affect the responses… CONTINUE READING