Propofol inhibits phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rat aortic smooth muscle.

@article{Yu2006PropofolIP,
  title={Propofol inhibits phorbol 12, 13-dibutyrate-induced, protein kinase C-mediated contraction of rat aortic smooth muscle.},
  author={Jingui Yu and Tetsuya Kakutani and Kazuhiro Mizumoto and Akira Hasegawa and Yoshio Hatano},
  journal={Acta anaesthesiologica Scandinavica},
  year={2006},
  volume={50 9},
  pages={1131-8}
}
BACKGROUND Propofol induces dose-dependent vasodilation and hypotension in the clinical situation, and protein kinase C (PKC)-mediated Ca2+ sensitization plays an important role in vascular smooth muscle contraction. This study is designed to examine the effects of propofol on the active phorbol ester (phorbol 12, 13-dibutyrate; PDBu)-induced, PKC-mediated… CONTINUE READING