Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.

@article{Han2016PropofolIH,
  title={Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.},
  author={Sheng-na Han and Ying Ying Jing and Lin-lin Yang and Zhao Zhang and Li-Rong Zhang},
  journal={European journal of pharmacology},
  year={2016},
  volume={791},
  pages={
          168-178
        }
}
QT interval prolongation, a potential risk for arrhythmias, may result from gene polymorphisms relevant to cardiomyocyte repolarization. Another noted cause of QT interval prolongation is the administration of chemical compounds such as anesthetics, which may affect a specific type of cardiac K+ channel encoded by the human ether-a-go-go-related gene (hERG). hERG K+ current was recorded using whole-cell patch clamp in human embryonic kidney (HEK293) cells expressing wild type (WT) or mutated… CONTINUE READING
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