Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells.

Abstract

QT interval prolongation, a potential risk for arrhythmias, may result from gene polymorphisms relevant to cardiomyocyte repolarization. Another noted cause of QT interval prolongation is the administration of chemical compounds such as anesthetics, which may affect a specific type of cardiac K+ channel encoded by the human ether-a-go-go-related gene (hERG… (More)
DOI: 10.1016/j.ejphar.2016.08.028

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