Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation.

@article{Zhu2009PropofolIA,
  title={Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation.},
  author={Shengmei Zhu and Xiaoxing Xiong and Yue-ying Zheng and Cai-fei Pan},
  journal={Anesthesia and analgesia},
  year={2009},
  volume={109 5},
  pages={1493-9}
}
BACKGROUND Aquaporin 4 (AQP4) plays a key role in maintaining water balance in the central nervous system, and its dysfunction may lead to brain edema. Previous studies have suggested that propofol may be involved in neuroprotection by preventing brain edema. In this study, we examined the effects of propofol on edema and assessed its neuroprotective… CONTINUE READING