Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.

Abstract

Activation of native IH pacemaker channels and channels formed on heterologous expression of some isoforms of their pore forming HCN (hyperpolarization-activated, cyclic nucleotide-regulated) subunits is inhibited by the intravenous general anaesthetic propofol (2,6-diisopropylphenol). Here, we show that inhibition of homomeric HCN1 channels is mediated… (More)

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Cite this paper

@article{Lyashchenko2007PropofolIH, title={Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.}, author={Alex K. Lyashchenko and Kacy J. Redd and Jay W. Yang and Gareth R. Tibbs}, journal={The Journal of physiology}, year={2007}, volume={583 Pt 1}, pages={37-56} }