Propofol induction reduces the capacity for neural information integration: Implications for the mechanism of consciousness and general anesthesia

@article{Lee2009PropofolIR,
  title={Propofol induction reduces the capacity for neural information integration: Implications for the mechanism of consciousness and general anesthesia},
  author={UnCheol Lee and George A. Mashour and Seunghwan Kim and Gyujeong Noh and Byung-Moon Choi},
  journal={Consciousness and Cognition},
  year={2009},
  volume={18},
  pages={56-64}
}

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References

SHOWING 1-10 OF 27 REFERENCES
Invariant Reversible QEEG Effects of Anesthetics
TLDR
A common set of neuroanatomical regions appeared to be the locus of the most probable generators of the observed EEG changes, with prefrontal and frontal regions of each hemisphere becoming more closely coupled and anterior and posterior regions on each hemisphere, as well as homologous regions between the two hemispheres, uncoupling.
Consciousness Unbound: Toward a Paradigm of General Anesthesia
TLDR
Although general anesthesia may be mediated by complex pharmacologic and neurologic mechanisms, it should not abandon the quest for a unitary hypothesis, because the lack of a guiding paradigm may ultimately impede the development of investigation.
Toward a Unified Theory of Narcosis: Brain Imaging Evidence for a Thalamocortical Switch as the Neurophysiologic Basis of Anesthetic-Induced Unconsciousness
TLDR
A model of anesthetic-induced unconsciousness is introduced to explain how the plethora of effects anesthetics have on cellular functioning ultimately all converge on a single neuroanatomic/neurophysiologic system, thus providing for a unitary physiologic theory of narcosis related to consciousness.
The Anesthetic Cascade: A Theory of How Anesthesia Suppresses Consciousness
TLDR
A body of evidence has now accumulated demonstrating that for many anesthetic agents, the dose required to suppress consciousness exceeds the amnestic dose but is substantially less then that required for surgical immobility during noxious stimuli, suggesting that these three dimensions may be mediated by different regions of the central nervous system.
Nonlinear Changes in Brain Dynamics during Emergence from Sevoflurane Anesthesia: Preliminary Exploration Using New Software
TLDR
The dynamical stages of emergence from sevoflurane anesthesia into consciousness demonstrate a classic route toward chaos, but the presence of chaos in the conscious state remains unproven.
Functional connectivity changes with concentration of sevoflurane anesthesia
Low-frequency oscillations (<0.08 Hz) have been detected in functional magnetic resonance imaging studies, and appear to be synchronized between functionally related areas. The effect of anesthetic
Breakdown of Cortical Effective Connectivity During Sleep
TLDR
The fading of consciousness during certain stages of sleep may be related to a breakdown in cortical effective connectivity, as measured by transcranial magnetic stimulation and high-density electroencephalography.
Integrating the Science of Consciousness and Anesthesia
TLDR
The neural correlates of consciousness that may be targets of general anesthetics are described, and an integrated approach to the science of consciousness and anesthesia is suggested.
An information integration theory of consciousness
  • G. Tononi
  • Psychology, Biology
    BMC Neuroscience
  • 2004
TLDR
The information integration theory accounts, in a principled manner, for several neurobiological observations concerning consciousness, including the association of consciousness with certain neural systems rather than with others; the fact that neural processes underlying consciousness can influence or be influenced by neural processes that remain unconscious; the reduction of consciousness during dreamless sleep and generalized seizures.
An effective correlation dimension and burst suppression ratio of the EEG in rat. Correlation with sevoflurane induced anaesthetic depth
TLDR
Both correlation dimension and burst suppression ratio are related to anaesthetic depth and are affected by noxious stimuli.
...
1
2
3
...