Propofol-induced relaxation of rat mesenteric arteries: evidence for a cyclic GMP-mediated mechanism.

  title={Propofol-induced relaxation of rat mesenteric arteries: evidence for a cyclic GMP-mediated mechanism.},
  author={R. Liu and M G Lang and Thomas Felix L{\"u}scher and Manuel Kaufmann},
  journal={Journal of cardiovascular pharmacology},
  volume={32 5},
Experiments were designed to evaluate whether guanosine 3',5'-cyclic monophosphate (cGMP)-mediated mechanisms contribute to vasodilation via propofol in rat mesenteric resistance arteries. Ring segments were suspended in the myograph system for isometric tension recording, and responses to propofol were tested in the presence and absence of methylene blue (MB), an inhibitor of guanylate cyclase. At concentrations > or = 1 microM, propofol caused concentration-dependent relaxation of vessel… 

The Mechanisms of Propofol-Mediated Hyperpolarization of In Situ Rat Mesenteric Vascular Smooth Muscle

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The effects of propofol on vascular function in mesenteric arteries of the aging rat.

  • F. GragasinS. Davidge
  • Medicine, Biology
    American journal of physiology. Heart and circulatory physiology
  • 2009
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Protein Kinase C Isoforms Distinctly Regulate Propofol-induced Endothelium-dependent and Endothelium-independent Vasodilation

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Mechanisms of cellular synchronization in the vascular wall. Mechanisms of vasomotion.

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Effects of General Anesthetics on Regulation of the Peripheral Vasculature

Current knowledge about the effects of general anesthetics on both the extrinsic intrinsic regulatory mechanisms of peripheral vascular control and the large number and complexity of these known mechanisms has made it extremely difficult to determine which are significant.

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Vascular actions of general anesthetics are reviewed and their underlying mechanisms, their in vivo relevance, and the future of research for general anesthetic vascular pharmacology are discussed.



Propofol-Associated Dilation of Rat Distal Coronary Arteries Is Mediated by Multiple Substances, Including Endothelium-Derived Nitric Oxide

It is concluded that propofol has a direct vasodilatory effect on distal coronary arteries in rats and is primarily endothelium-dependent and is mediated by multiple substances, including nitric oxide (NO) and a vasodILatory prostanoid.

Effects of propofol on isolated rabbit mesenteric arteries and veins.

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Propofol Produces Endothelium‐Independent Vasodilation and May Act as a Ca2+Channel Blocker

It is concluded that vasodilation produced by propofol is not endothelium-dependent but is likely due to blockade of voltage-gated influx of extracellular Ca2+.

Vasodilation and Mechanism of Action of Propofol in Porcine Coronary Artery

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Modification of Endothelium-Dependent Relaxation by Propofol, Ketamine, and Midazolam

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Differential Relaxant Effect of High Concentrations of Intravenous Anesthetics on Endothelin‐Constricted Proximal and Distal Canine Coronary Arteries

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Cyclic GMP Causes Ca2+ Desensitization in Vascular Smooth Muscle by Activating the Myosin Light Chain Phosphatase*

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