Propofol induced diverse and subtype-specific translocation of PKC families.

@article{Miyahara2018PropofolID,
  title={Propofol induced diverse and subtype-specific translocation of PKC families.},
  author={Takeshi Miyahara and Naoko Adachi and Takahiro Seki and Izumi Hide and Shigeru Tanaka and Naoaki Saito and Masahiro Irifune and Norio Sakai},
  journal={Journal of pharmacological sciences},
  year={2018},
  volume={137 1},
  pages={
          20-29
        }
}
Propofol is the most commonly used anesthetic. Immunohistochemical studies have reported that propofol translocated protein kinase Cs (PKCs) in cardiomyocyte in a subtype-specific manner; however detailed features of the propofol-induced translocation of PKCs remain unknown. In this study, we performed real-time observation of propofol-induced PKC translocation in SH-SY5Y cells expressing PKCs fused with a fluorescent protein. Propofol unidirectionally translocated γPKC-GFP, a conventional PKC… CONTINUE READING
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