Propofol in subanesthetic doses terminates status epilepticus in a rodent model.

@article{Holtkamp2001PropofolIS,
  title={Propofol in subanesthetic doses terminates status epilepticus in a rodent model.},
  author={Martin Holtkamp and Xin Tong and Matthew C. Walker},
  journal={Annals of neurology},
  year={2001},
  volume={49 2},
  pages={260-3}
}
Status epilepticus is commonly refractory to first-line therapy, and thus better treatments are needed. We have investigated an experimental model of drug-resistant self-sustaining status epilepticus (SSSE) induced by 2 hours of perforant path stimulation. Propofol in subanesthetic doses administered shortly after the end of stimulation and also after a further 3 hours of SSSE terminated the SSSE without recurrence. This finding calls for a trial of propofol in refractory status epilepticus and… CONTINUE READING

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This finding calls for a trial of propofol in refractory status epilepticus and also raises the possibility of using it as first - line therapy .
Propofol in subanesthetic doses terminates status epilepticus in a rodent model .
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