Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation.

@article{Iizuka2017PropofolfentanylII,
  title={Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation.},
  author={Tomoya Iizuka and Kenichi Masui and Takako Miyabe-Nishiwaki and Hideko Kanazawa and Ryohei Nishimura},
  journal={Research in veterinary science},
  year={2017},
  volume={115},
  pages={34-42}
}
The objective of this study was to characterize the propofol-fentanyl interaction in Beagles for four pharmacodynamic endpoints: apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation. After anesthesia was induced with varying combinations of propofol and fentanyl, the pharmacodynamic endpoints were assessed in intubated dogs (n=6) using the cross-over design. Effective concentrations of propofol plasma concentration (Cp) and fentanyl Cp were assessed using… CONTINUE READING
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