Propofol facilitates glutamatergic transmission to neurons of the ventrolateral preoptic nucleus.


BACKGROUND There is much evidence that the sedative component of anesthesia is mediated by gamma-aminobutyric acid type A (GABA(A)) receptors on hypothalamic neurons responsible for arousal, notably in the tuberomammillary nucleus. These GABA(A) receptors are targeted by gamma-aminobutyric acid-mediated (GABAergic) neurons in the ventrolateral preoptic area… (More)
DOI: 10.1097/ALN.0b013e3181bf1d79