Propofol effective concentration 50 and its relationship to bispectral index.

@article{Irwin2002PropofolEC,
  title={Propofol effective concentration 50 and its relationship to bispectral index.},
  author={Michael G Irwin and Theresa W C Hui and Stewart E. Milne and Gavin N. C. Kenny},
  journal={Anaesthesia},
  year={2002},
  volume={57 3},
  pages={242-8}
}
Sixty unpremedicated healthy adult patients were studied during induction of anaesthesia with intravenous propofol delivered by a 'Diprifusor' target-controlled infusion. Bispectral index (BIS) and spectral edge frequency (SEF95) were measured concurrently with the predicted blood and effect site propofol concentrations. Logistic regression was used to calculate the predicted propofol blood and effect site concentrations required to produce unconsciousness and no response to a noxious stimulus… CONTINUE READING