Propofol attenuates lung endothelial injury induced by ischemia-reperfusion and oxidative stress.

@article{Balyasnikova2005PropofolAL,
  title={Propofol attenuates lung endothelial injury induced by ischemia-reperfusion and oxidative stress.},
  author={Irina V. Balyasnikova and David J Visintine and Helena B Gunnerson and Chanannait Paisansathan and Verna L. Baughman and Richard D Minshall and Sergei M Danilov},
  journal={Anesthesia and analgesia},
  year={2005},
  volume={100 4},
  pages={929-36}
}
Lung dysfunction after cardiopulmonary bypass and lung transplantation results from oxidant-mediated cellular damage. Previously, we observed the shedding of angiotensin-converting enzyme (ACE) from the endothelial cell surface to be a more sensitive and earlier marker of oxidative lung endothelial injury than lung wet-to-dry weight ratio. The aim of this study was to evaluate the potential of the anesthetic propofol, which has antioxidant properties, to prevent oxidative lung injury by… CONTINUE READING
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