Propofol Regulates the Surface Expression of GABAA Receptors: Implications in Synaptic Inhibition.

Abstract

BACKGROUND The anesthetic propofol is thought to induce rapid hypnotic sedation by potentiating γ-aminobutyric acid receptor (GABAAR) activity. Little is known about the molecular mechanisms of propofol in modulating inhibitory synaptic transmission. We aimed to investigate the role of propofol in modulating surface expression of GABAARs. METHODS C57BL/6… (More)
DOI: 10.1213/ANE.0000000000000884

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