Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling

@article{Li2018PropofolPH,
  title={Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling},
  author={Xiaojun Li and L. Yao and Qianlei Liang and Hangying Qu and Hui Cai},
  journal={Oxidative Medicine and Cellular Longevity},
  year={2018},
  volume={2018}
}
Objectives Propofol is a popular anesthetic drug that is neuroprotective. However, the mechanisms of propofol for hippocampal neuroprotection remain elusive. This study is aimed at investigating the neuroprotective effect and mechanism of propofol in hippocampal neurons exposed to ischemia-reperfusion (I/R) injury. Methods Hypoxia-reoxygenated (H/R) HT-22 cells were used to mimic I/R injury of the hippocampus in vitro. An MTT assay was used to determine cell viability. Cell apoptosis was… 
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This work aimed to identify whether and how propofol improved hypoxia‐induced impairment of BBB integrity and to investigate the neuroprotective effect of prop ofol on blood‐brain barrier integrity.
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