Propofol Inhibits Superoxide Production, Elastase Release, and Chemotaxis in Formyl Peptide–Activated Human Neutrophils by Blocking Formyl Peptide Receptor 1

@article{Yang2013PropofolIS,
  title={Propofol Inhibits Superoxide Production, Elastase Release, and Chemotaxis in Formyl Peptide–Activated Human Neutrophils by Blocking Formyl Peptide Receptor 1},
  author={Shun‐Chin Yang and Pei-Jen Chung and Chiu-Ming Ho and Chan-Yen Kuo and Min-Fa Hung and Yin-Ting Huang and Wen-yi Chang and Ya-Wen Chang and Kwok‐Hon Chan and Tsong-Long Hwang},
  journal={The Journal of Immunology},
  year={2013},
  volume={190},
  pages={6511 - 6519}
}
Neutrophils play a critical role in acute and chronic inflammatory processes, including myocardial ischemia/reperfusion injury, sepsis, and adult respiratory distress syndrome. Binding of formyl peptide receptor 1 (FPR1) by N-formyl peptides can activate neutrophils and may represent a new therapeutic target in either sterile or septic inflammation. Propofol, a widely used i.v. anesthetic, has been shown to modulate immunoinflammatory responses. However, the mechanism of propofol remains to be… 
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