Propofol Attenuates Peroxynitrite-mediated DNA Damage and Apoptosis in Cultured Astrocytes: An Alternative Protective Mechanism

@article{Acquaviva2004PropofolAP,
  title={Propofol Attenuates Peroxynitrite-mediated DNA Damage and Apoptosis in Cultured Astrocytes: An Alternative Protective Mechanism},
  author={Rosaria Acquaviva and Agata Campisi and Paolo Murabito and Giuseppina Raciti and Roberto Avola and Salvatore Mangiameli and Ilenia Musumeci and Maria Luisa Barcellona and Angelo Vanella and Giovanni Li Volti},
  journal={Anesthesiology},
  year={2004},
  volume={101},
  pages={1363-1371}
}
Background:The concentration of peroxynitrite in the brain increases after central nervous system injuries. The authors hypothesized that propofol, because of its particular chemical structure, mitigates the effects of peroxynitrite-mediated oxidative stress and apoptosis by the induction of heme oxygenase (HO)-1 in primary cultured astroglial cells. Methods:Primary cultured astroglial cells were incubated for 18 h with a known peroxynitrite donor (3 mm SIN-1) in the presence or absence of… 

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