Propofol‐induced calcium signalling and actin reorganization within breast carcinoma cells

@article{Garib2005PropofolinducedCS,
  title={Propofol‐induced calcium signalling and actin reorganization within breast carcinoma cells},
  author={Victoria Garib and Kerstin Lang and Bernd Niggemann and K. S. Z{\"a}nker and Ludwig Brandt and Thomas Dittmar},
  journal={European Journal of Anaesthesiology},
  year={2005},
  volume={22},
  pages={609–615}
}
Background and objective: MDA‐MB‐468 breast carcinoma cells respond to non‐volatile anaesthetics such as propofol with an increased migration. Here we investigated the relationship between GABA‐A receptor modulators, the mode of calcium oscillation and actin reorganization with regard to breast carcinoma cell migration. Methods: Expression of the GABA‐A receptor was determined by Western blot analysis. Calcium‐imaging experiments of individual MDA‐MB‐468 cells as well as visualization of the F… 
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Effects of Propofol on Several Membrane Characteristics of Cervical Cancer Cell Lines
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A close relationship is demonstrated between changes in cell membrane ultrastructure and cytoskeletal alterations (F-actin) in propofol-treated HeLa cells, which can be directly reflected by changes in cellular morphology, as assessed by AFM.
GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells.
Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2
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Propofol induces proliferation and promotes invasion of GC cells through activation of Nrf2 and loss of NRF2 by shRNA reversed the effect of propofol on cell proliferation, apoptosis, and invasion.
Propofol inhibits growth and invasion of pancreatic cancer cells through regulation of the miR-21/Slug signaling pathway.
TLDR
Propofol can effectively inhibit invasion and induce apoptosis of PANC-1 cells by regulating miR-21/Slug signals.
Propofol reduces MMPs expression by inhibiting NF-κB activity in human MDA-MB-231 cells.
Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231.
TLDR
Propofol increased the proliferation of human breast cancer MDA-MB‑231 cells, which was at least partially associated with the inhibition of the expression of p53, and induced cell migration, whichwas involved in the activation of the Nrf2 pathway.
Propofol inhibited invasion and decreased expression of PMEPA 1 in MDA-MB-231 cells
TLDR
It is shown that propofol, a drug commonly used during breast cancer resection surgery, may inhibit the progression of TNBC and warrants additional investigation as a possible therapeutic treatment and anesthesia choice for TNBC patients.
Involvement of cationic channels in proliferation and migration of human mesenchymal stem cells.
Propofol Inhibits Platelet-derived Growth Factor-stimulated Migration in Rat Aortic Smooth Muscle Cells
TLDR
The present results suggest that propofol induces the diminution of PDGF-stimulated RASMC migration and this response may be associated with dephosphorylation of cofilin mediated by the protein phosphatase 2A-dependent pathway.
GABA(A) Receptor Pi (GABRP) Stimulates Basal-like Breast Cancer Cell Migration through Activation of Extracellular-regulated Kinase 1/2 (ERK1/2)*
TLDR
A GABRP-ERK1/2-cytokeratin axis maintains BLBC migration, and findings suggest that targeting this new signaling axis may have therapeutic potential in BLBC.
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