Propofol‐induced calcium signalling and actin reorganization within breast carcinoma cells

  title={Propofol‐induced calcium signalling and actin reorganization within breast carcinoma cells},
  author={Victoria Garib and Kerstin Lang and Bernd Niggemann and K. S. Z{\"a}nker and Ludwig Brandt and Thomas Dittmar},
  journal={European Journal of Anaesthesiology},
Background and objective: MDA‐MB‐468 breast carcinoma cells respond to non‐volatile anaesthetics such as propofol with an increased migration. Here we investigated the relationship between GABA‐A receptor modulators, the mode of calcium oscillation and actin reorganization with regard to breast carcinoma cell migration. Methods: Expression of the GABA‐A receptor was determined by Western blot analysis. Calcium‐imaging experiments of individual MDA‐MB‐468 cells as well as visualization of the F… 

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