Propofol: A New Intravenous Anesthetic

@article{Sebel1989PropofolAN,
  title={Propofol: A New Intravenous Anesthetic},
  author={Peter s. Sebel and Jane D. Lowdon},
  journal={Anesthesiology},
  year={1989},
  volume={71},
  pages={260–277}
}
Assessing Propofol Induction of Anesthesia Dose Using Bispectral Index Analysis
TLDR
The dose of propofol assessed by BIS analysis results in an important reduction of prop ofol requirement without side effects.
Prolonged spontaneous movement following emergence from propofol/nitrous oxide anesthesia.
TLDR
A patient who, despite an intact mental status, experienced new onset of involuntary myoclonic-dystonic motor movement which lasted several days following emergence from a propofol/nitrous oxide anesthetic is presented.
Induction Agents for Endotracheal Intubation in Severe Sepsis and Septic Shock
TLDR
The management of severe sepsis and septic shock remains to this day one of the great challenges in medical care and cross the threshold of multiple medical disciplines.
Assessment of propofol anesthesia in the rabbit
Sedation and Analgesia for Diagnostic and Therapeutic Procedures
Propofol in patients with cardiac disease
  • N. Searle, P. Sahab
  • Medicine
    Canadian journal of anaesthesia = Journal canadien d'anesthesie
  • 1993
TLDR
Compared with other iv anaesthetics, the induction dose of propofol has a relatively higher incidence of respiratory depression, short-lived apnoea and blood pressure reduction that may occasionally be marked.
Comparison of the effects of patient controlled analgesia (PCA) using dexmedetomidine and propofol during septoplasty operations: a randomized clinical trial
TLDR
Dexmedetomidine can be used safely as an analgesic and sedation drug in septoplastic surgery, and patient satisfaction via patient-controlled anesthesia and analgesic demand was high.
Propofol Suppresses Macrophage Functions and Modulates Mitochondrial Membrane Potential and Cellular Adenosine Triphosphate Synthesis
TLDR
A clinically relevant concentration of propofol can suppress macrophage functions, possibly through inhibiting their mitochondrial membrane potential and adenosine triphosphate synthesis instead of direct cellular toxicity.
Efficacy and Safety of HSK3486 for Anesthesia/Sedation in Patients Undergoing Fiberoptic Bronchoscopy: A Multicenter, Double-Blind, Propofol-Controlled, Randomized, Phase 3 Study
TLDR
HSK3486 exhibited non-inferiority anesthesia/sedation compared to propofol in patients undergoing fiberoptic bronchoscopy, and had a good safety profile with a lower incidence of pain on injection.
“The Induction Dose with Ketamine and Midazolam Co-Induction to Propofola”
TLDR
This study showed that hemodynamic variables were maintained within the physiological range with midazolam and ketamine co-induction, however, lesser degree of decrease in mean arterial pressure was seen with ketamine but the heart rate was higher.
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