Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.

@article{Eckly2010ProplateletFD,
  title={Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.},
  author={Anita Eckly and J-Y Rinckel and Patricia Laeuffer and J. P. Cazenave and François Lanza and Christian Gachet and Catherine L{\'e}on},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2010},
  volume={8 10},
  pages={2243-51}
}
BACKGROUND  Inactivation of the mouse Myh9 gene (Myh9Δ) or its mutation in MYH9-related diseases leads to macrothrombocytopenia. Paradoxically, previous studies using in vitro differentiated megakaryocytes showed an increased capacity for proplatelet formation when myosin was absent or inhibited. METHODS  To explore the origin of the thrombocytopenia induced by myosin deficiency, we studied proplatelet formation using bone marrow explants of wild-type (WT) and Myh9Δ mouse where megakaryocytes… CONTINUE READING
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