Propionibacterium acnes Resistance: A Worldwide Problem

@article{Eady2003PropionibacteriumAR,
  title={Propionibacterium acnes Resistance: A Worldwide Problem},
  author={E.A. Eady and Max Gloor and James J. Leyden},
  journal={Dermatology},
  year={2003},
  volume={206},
  pages={54 - 56}
}
Antibiotic therapy directed against Propionibacterium acnes has been a mainstay of treatment for more than 40 years. Despite years of widespread use of systemic tetracyclines and erythromycin, change in P. acnes sensitivity to antibiotics was not seen until the early 1980s. The first clinically relevant changes in P. acnes antibiotic sensitivity were found in the USA shortly after the introduction of topical formulations of erythromycin and clindamycin. By the late 1980s, P. acnes strains with… 
View on PubMed
doi.org
163 Citations
Highly Influential Citations
2
Background Citations
36

163 Citations

Citation Type

Citation Type

Antibiotic susceptibility of Propionibacterium acnes isolated from acne vulgaris in Korea
TLDR
Investigation of the isolation rate of P. acnes and its antibiotic susceptibility to widely used antibiotics in acne in Korea found it to be low, but at this point, there is an increasing trend of MIC.
Propionibacterium acnes, an emerging pathogen: from acne to implant-infections, from phylotype to resistance.
TLDR
In case of a biofilm growth mode, the therapeutic strategy should be discussed, according to the resistance phylotype and phenotype so as to optimize the treatment of these severe infections.
Antimicrobial susceptibilities of Propionibacterium acnes isolated from patients with acne vulgaris
TLDR
Sequencing analysis revealed that all of the erythromycin‐resistant strains had a mutation in the peptidyl transferase region of the 23S rRNA gene: G2057A, A2058G, or A2059G, and showed that P. acnes resistance to macrolides is caused by a mutations in the23S r RNA gene, and has been increasing in Japan.
Characterisation of antibiotic-resistant Propionibacterium acnes from acne vulgaris and other diseases
TLDR
It is found that acne patients in Stockholm treated with antibiotics had a significantly higher risk of carrying resistant P. acnes strains, than acne patients who did not receive such a treatment, and it is demonstrated that antimicrobial resistance has emerged among P. Acnes strains isolated from different severe, lifethreatening infections in Europe.
Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm.
TLDR
In the group of patients treated with antibiotics, resistant P. acnes strains were significantly more often isolated from antibiotic-treated patients with moderate to severe acne than from non-antibiotic- treated patients (odds ratio, 3.8; P=0.01).
Antibiotic Resistance in Acne: Mechanisms, Complications and Management
TLDR
A better understanding of acne pathogenesis, the subtypes of Propionibacterium, homeostasis of the skin microbiota, and the mechanisms of antibiotic resistance would be useful in the selection of narrow-spectrum or species-specific antimicrobials, as well as the non-antimicrobial, anti-inflammatory treatment of acne.
Antibiotic resistance of microbial strains isolated from Korean acne patients
TLDR
This study shows that antibiotic‐resistant strains have been increasing in Korea acne patients, and a higher proportion of P. acnes isolates were resistant to clindamycin and erythromycin than to any other antibiotics tested.
Non-antibiotic Isotretinoin Treatment Differentially Controls Propionibacterium acnes on Skin of Acne Patients
TLDR
The role of tetracycline’s and macrolides, which are currently first line treatments in dermatology, might be reserved for severe or life-threatening infections since current antibiotic stewardship guidelines from medical departments no longer prescribe these antibiotics for routine use.
Bacteriological resistance in acne: A call to action
  • B. Dréno
  • Medicine
    European Journal of Dermatology
  • 2016
TLDR
Correct and appropriate use of antibiotics in the treatment of acne will help to preserve their utility in the face of increasing antibiotic resistance but greater awareness of the issues is required among prescribing physicians.
Antimicrobial susceptibility of strains of Propionibacterium acnes isolated from inflammatory acne.
TLDR
The antimicrobial susceptibility of 53 strains of P. acnes isolated from skin specimens of inflammatory acne patients, at the clinical Hospital University of Chile was tested, and all isolates were susceptible to penicillin, minocycline, and nadifloxacin.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 22 REFERENCES
Antimicrobial susceptibility of Propionibacterium acnes isolated from acne vulgaris.
TLDR
The aim of the present study was to examine the antimicrobial susceptibility to 10 currently used antimicrobial agents of 50 strains of P. acnes, and found that oral MINO is the most useful treatment for acne vulgaris with minimal risk of bacterial resistance.
Propionibacterium acnes resistance to antibiotics in acne patients.
The minimal inhibitory concentration (MIC) of Propionibacterium acnes in seventy-five acne patients receiving long-term antibiotic therapy demonstrated the emergence of resistant strains. The mean…
In Vitro activity of 6 antimicrobials against propionibacteria isolates from untreated acne papulopustulosa.
TLDR
It is shown that P. acnes and P. granulosum strains are not suppressed even at higher erythromycin concentrations up to 256 μg/ml, and a therapeutic effect may be possible.
Bacterial Resistance in Acne
TLDR
Understanding is gained of those factors which encourage resistance development and can identify those patients most likely to possess resistant propionibacterial floras, which could help prevent the emergence of resistance in P. acnes.
Tetracycline‐resistant propionibacteria from acne patients are cross‐resistant to doxycycline, but sensitive to minocycline
TLDR
Results indicate that tetracycline‐resistant propionibacteria should be considered clinically minocycline sensitive, if patients who harbour such strains are prescribed 100 mg b.d. and the recommended dose of minocyCline for treating acne should be re‐assessed.
Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA
The genetic basis of erythromycin resistance in cutaneous propionibacteria was determined by comparing the nucleotide sequences of the peptidyl transferase region in the 23S rRNAs from 9 susceptible…
Erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure
TLDR
It is suggested that the use of oral erythromycin and/or topical clindamycin encourages the development of resistant propionibacteria and that the emergence of resistant strains is associated with therapeutic failure in erystromycin‐treated patients.
Phenotypic and genotypic characterization of antibiotic‐resistant Propionibacterium acnes isolated from acne patients attending dermatology clinics in Europe, the U.S.A., Japan and Australia
TLDR
Propionibacterium acnes is the target of antimicrobial treatments for acne vulgaris and the molecular basis of resistance, via mutations in genes encoding 23S and 16S rRNA, has so far only been elucidated for isolates from the U.K.
Laboratory induction and clinical occurrence of combined clindamycin and erythromycin resistance in Corynebacterium acnes.
TLDR
Corynebacterium acnes strains cross-resistant to clindamycin and erythromycin were observed following long-term selection or mutagenic treatment in the laboratory and it is suggested that this resistance may result from an alteration of the 50S ribosomal subunit.
Macrolide-lincosamide-streptogramin B (MLS) resistance in cutaneous propionibacteria: definition of phenotypes.
TLDR
The majority of erythromycin resistant propionibacteria express MLS resistance which is phenotypically similar to that coded for by several well characterized RNA methylase (erm) genes.
...
1
2
3
...