Propionibacterium acnes: an update on its role in the pathogenesis of acne

  title={Propionibacterium acnes: an update on its role in the pathogenesis of acne},
  author={Claire Beylot and Nicole Auffret and Florence Poli and Jean Paul Claudel and Marie Th{\'e}r{\`e}se Leccia and P. Del giudice and Brigitte Dr{\'e}no},
  journal={Journal of the European Academy of Dermatology and Venereology},
  • C. BeylotN. Auffret B. Dréno
  • Published 1 March 2014
  • Biology, Medicine
  • Journal of the European Academy of Dermatology and Venereology
In recent years, significant progress has been made in the understanding of the pathophysiological mechanisms of acne and the role of Propionibacterium acnes. With this review, the authors aim to provide an update on the current understanding of the role of P. acnes in the development of acne lesions and analysing the potential implications for future treatments. A total of 188 articles published between January 1980 and March 2013 were searched using key words such as acne, P. acnes… 

Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates

Results of the most recent biochemical and genomic investigations that led to the new taxonomic classification of P. acnes renamed Cutibacterium acnes are provided, providing an overview of the factors that could participate in the virulence and in the antimicrobial resistance of acne‐associated strains.

Cutibacterium acnes Phylotype I and II Strains Interact Differently With Human Skin Cells

Key elements of the host-pathogen interaction were studied for a collection of C. acnes strains, belonging to phylotype I and II, including association with HaCaT keratinocytes and SZ95 sebocytes, showing association of all C. Acnes strains to both skin cell lines, with a significantly higher association of type I strains compared to type II strains.

From new findings in acne pathogenesis to new approaches in treatment

  • H. Gollnick
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2015
Acne is a chronic disease of the pilosebaceous unit which is most common during adolescence. Four factors are believed to play a key role in the development of acne lesions: excess sebum production,

Recent progress in the research about Propionibacterium acnes strain diversity and acne: pathogen or bystander?

An update on the recent understanding of research about P. acnes strain diversity and acne is provided, analyzing the potential implications for clinical applications and developing therapeutic drugs by pinpointing specific targets of the pathogenic strain only.

Antibacterial Susceptibility Testing of Cutibacterium acnes in Acne Vulgaris Patients

Patients with AV have higher rates of resistance to erythromycin than the CG, while resistance to clindamycin is comparable, and Resistance data showed no statistically significant association between use of eryhromycin and clind amycin and the development of resistance.

Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies

This extensive review will cover the current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. Acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data.

Typing of Propionibacterium acnes: a review of methods and comparative analysis

Type systems for this bacterium have taken on an increased importance as different types of P. acnes have been found to be associated with different disease states, including acne.

Propionibacterium acnes activates the NLRP3 inflammasome in human sebocytes.

  • Z. LiD. Choi M. Im
  • Biology, Medicine
    The Journal of investigative dermatology
  • 2014
The results suggest that human sebocytes are important immunocompetent cells that induce the NLRP3 inflammasome, and that P. acnes-induced IL-1β activation in sebaceous glands may have a role in combating skin infections and in acne pathogenesis.



Acne vaccines targeting Propionibacterium acnes.

  • M. KaoC-M Huang
  • Biology, Medicine
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
  • 2009
A bioengineering approach was utilized to design a new human acne model using tissue chamber, which is shown to produce in mice a microenvironment similar to human acne inflammation, and can be utilized in future studies in developing therapeutic acne vaccines and designing possible combined treatment of acne vaccine with alternative acne treatments.

Heat‐killed Propionibacterium acnes is capable of inducing inflammatory responses in skin

Killed P. acnes is capable of inducing inflammation in skin suggesting that therapies that have both bactericidal and anti‐inflammatory effects may result in a more effective treatment of patients with acne than treatments that are bactericidal alone.

Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors.

The findings suggest that P. acnes modulates the antimicrobial peptide and chemokine expression of keratinocytes and thereby contributes to the recruitment of inflammatory cells to the sites of infections.

Correlation between Propionibacterium acnes Biotypes, Lipase Activity and Rash Degree in Acne Patients

P. acnes B3 had the highest lipase activity and might have the greatest influence on skin rash in acne patients, and was isolated from more severe skin rashes than those of the other biotypes.

Vaccination Targeting a Surface Sialidase of P. acnes: Implication for New Treatment of Acne Vulgaris

An acne vaccine targeting a cell wall-anchored sialidase of Propionibacterium acnes is created and indicated that acne vaccines open novel therapeutic avenues for acne vulgaris and other P. acnes-associated diseases.

Cutaneous induction of corticotropin releasing hormone by Propionibacterium acnes extracts

The result indicates that P. acnes by stimulating the production of CRH can both modulate the differentiation of keratinocytes and increase the local inflammation, arguing that this bacterium plays a role not only in the development of inflammatory acne lesions but also in the formation of the microcomedo in the early stages of acne.

Population Genetic Analysis of Propionibacterium acnes Identifies a Subpopulation and Epidemic Clones Associated with Acne

Comparison of five genomes representing acne- and health-associated clones revealed multiple both cluster- and strain-specific genes that suggest major differences in ecological preferences and redefines the spectrum of disease-associated virulence factors.

Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro.

Results provide previously unreported evidence that P. acnes directly participates in the augmentation of sebaceous lipogenesis through a proposed mechanism in which an increase of 15d-PGJ(2) production through the CYP pathway is closely associated with the enhancement of TG production.

Variable expression of immunoreactive surface proteins of Propionibacterium acnes.

Variation in the expression of PA-4687, 25957 and 5541 is evident amongst clinical isolates and is generated both by frameshifts associated with the putative signal peptide and by variable numbers of repeat regions toward the carboxy-terminus, potentially generating heterogeneity of molecular mass and antigenic variation.