Propionibacterium acnes: an update on its role in the pathogenesis of acne

@article{Beylot2014PropionibacteriumAA,
  title={Propionibacterium acnes: an update on its role in the pathogenesis of acne},
  author={Claire Beylot and Nicole Auffret and Florence Poli and Jean Paul Claudel and Marie Th{\'e}r{\`e}se Leccia and P. Del giudice and Brigitte Dr{\'e}no},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2014},
  volume={28}
}
  • C. BeylotN. Auffret B. Dréno
  • Published 1 March 2014
  • Biology, Medicine
  • Journal of the European Academy of Dermatology and Venereology
In recent years, significant progress has been made in the understanding of the pathophysiological mechanisms of acne and the role of Propionibacterium acnes. With this review, the authors aim to provide an update on the current understanding of the role of P. acnes in the development of acne lesions and analysing the potential implications for future treatments. A total of 188 articles published between January 1980 and March 2013 were searched using key words such as acne, P. acnes… 

Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates

Results of the most recent biochemical and genomic investigations that led to the new taxonomic classification of P. acnes renamed Cutibacterium acnes are provided, providing an overview of the factors that could participate in the virulence and in the antimicrobial resistance of acne‐associated strains.

Cutibacterium acnes Phylotype I and II Strains Interact Differently With Human Skin Cells

Key elements of the host-pathogen interaction were studied for a collection of C. acnes strains, belonging to phylotype I and II, including association with HaCaT keratinocytes and SZ95 sebocytes, showing association of all C. Acnes strains to both skin cell lines, with a significantly higher association of type I strains compared to type II strains.

From new findings in acne pathogenesis to new approaches in treatment

  • H. Gollnick
  • Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2015
Acne is a chronic disease of the pilosebaceous unit which is most common during adolescence. Four factors are believed to play a key role in the development of acne lesions: excess sebum production,

Recent progress in the research about Propionibacterium acnes strain diversity and acne: pathogen or bystander?

An update on the recent understanding of research about P. acnes strain diversity and acne is provided, analyzing the potential implications for clinical applications and developing therapeutic drugs by pinpointing specific targets of the pathogenic strain only.

Antibacterial Susceptibility Testing of Cutibacterium acnes in Acne Vulgaris Patients

Patients with AV have higher rates of resistance to erythromycin than the CG, while resistance to clindamycin is comparable, and Resistance data showed no statistically significant association between use of eryhromycin and clind amycin and the development of resistance.

Propionibacterium acnes and Acne Vulgaris: New Insights from the Integration of Population Genetic, Multi-Omic, Biochemical and Host-Microbe Studies

This extensive review will cover the current knowledge regarding the association of P. acnes phylogroups, clonal complexes and sequence types with acne vulgaris based on multilocus sequence typing of isolates, and direct ribotyping of the P. Acnes strain population in skin microbiome samples based on 16S rDNA metagenomic data.

Typing of Propionibacterium acnes: a review of methods and comparative analysis

Type systems for this bacterium have taken on an increased importance as different types of P. acnes have been found to be associated with different disease states, including acne.

Propionibacterium acnes activates the NLRP3 inflammasome in human sebocytes.

  • Z. LiD. Choi M. Im
  • Biology, Medicine
    The Journal of investigative dermatology
  • 2014
The results suggest that human sebocytes are important immunocompetent cells that induce the NLRP3 inflammasome, and that P. acnes-induced IL-1β activation in sebaceous glands may have a role in combating skin infections and in acne pathogenesis.
...

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Heat‐killed Propionibacterium acnes is capable of inducing inflammatory responses in skin

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Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors.

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Variation in the expression of PA-4687, 25957 and 5541 is evident amongst clinical isolates and is generated both by frameshifts associated with the putative signal peptide and by variable numbers of repeat regions toward the carboxy-terminus, potentially generating heterogeneity of molecular mass and antigenic variation.
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