Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria

@article{Jan2002PropionibacteriaIA,
  title={Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria},
  author={Gw{\'e}na{\"e}l Jan and A-S Belzacq and Delphine Haouzi and Annette Rouault and Didier M{\'e}tivier and Guido Kroemer and Catherine Brenner},
  journal={Cell Death and Differentiation},
  year={2002},
  volume={9},
  pages={179-188}
}
The genus Propionibacterium is composed of dairy and cutaneous bacteria which produce short-chain fatty acids (SCFA), mainly propionate and acetate, by fermentation. Here, we show that P. acidipropionici and freudenreichii, two species which can survive in the human intestine, can kill two human colorectal carcinoma cell lines by apoptosis. Propionate and acetate were identified as the major cytotoxic components secreted by the bacteria. Bacterial culture supernatants as well as pure SCFA… CONTINUE READING
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