Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia

  title={Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia},
  author={N. Nguyen and C. Morland and S. Gonz{\'a}lez and F. Rise and J. Storm-Mathisen and V. Gundersen and B. Hassel},
  journal={Journal of Neurochemistry},
  • N. Nguyen, C. Morland, +4 authors B. Hassel
  • Published 2007
  • Biology, Medicine
  • Journal of Neurochemistry
  • In propionic acidemia, propionate acts as a metabolic toxin in liver cells by accumulating in mitochondria as propionyl‐CoA and its derivative, methylcitrate, two tricarboxylic acid cycle inhibitors. Little is known about the cerebral metabolism of propionate, although clinical effects of propionic acidemia are largely neurological. We found that propionate was metabolized oxidatively by glia: [3‐14C]propionate injected into mouse striatum or cortex, gave a specific activity of glutamine that… CONTINUE READING
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