• DOI:10.1111/j.1471-4159.2006.04397.x
Corpus ID: 514557

Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia

@article{Nguyen2007PropionateIN,
  title={Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia},
  author={N. Nguyen and C. Morland and S. Gonz{\'a}lez and F. Rise and J. Storm-Mathisen and V. Gundersen and B. Hassel},
  journal={Journal of Neurochemistry},
  year={2007},
  volume={101}
}

N. Nguyen, C. Morland, +4 authors B. Hassel

Published 2007

Biology, Medicine

Journal of Neurochemistry

In propionic acidemia, propionate acts as a metabolic toxin in liver cells by accumulating in mitochondria as propionyl‐CoA and its derivative, methylcitrate, two tricarboxylic acid cycle inhibitors. Little is known about the cerebral metabolism of propionate, although clinical effects of propionic acidemia are largely neurological. We found that propionate was metabolized oxidatively by glia: [3‐14C]propionate injected into mouse striatum or cortex, gave a specific activity of glutamine that… CONTINUE READING

View on Wiley

onlinelibrary.wiley.com

Save to Library

Create Alert

Cite

Launch Research Feed