Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia

@article{Nguyen2007PropionateIN,
  title={Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia},
  author={N. Nguyen and C. Morland and S. Gonz{\'a}lez and F. Rise and J. Storm-Mathisen and V. Gundersen and B. Hassel},
  journal={Journal of Neurochemistry},
  year={2007},
  volume={101}
}
  • N. Nguyen, C. Morland, +4 authors B. Hassel
  • Published 2007
  • Biology, Medicine
  • Journal of Neurochemistry
  • In propionic acidemia, propionate acts as a metabolic toxin in liver cells by accumulating in mitochondria as propionyl‐CoA and its derivative, methylcitrate, two tricarboxylic acid cycle inhibitors. Little is known about the cerebral metabolism of propionate, although clinical effects of propionic acidemia are largely neurological. We found that propionate was metabolized oxidatively by glia: [3‐14C]propionate injected into mouse striatum or cortex, gave a specific activity of glutamine that… CONTINUE READING
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    References

    SHOWING 1-10 OF 62 REFERENCES
    Effect of Propionic Acid on Fatty Acid Oxidation and Ureagenesis
    • 38
    • PDF
    Trafficking of Amino Acids between Neurons and Glia In Vivo. Effects of Inhibition of Glial Metabolism by Fluoroacetate
    • 165
    The effect of malate on propionate mitochondrial toxicity.
    • 9
    • Highly Influential
    Pyruvate carboxylation in neurons
    • B. Hassel
    • Medicine, Biology
    • Journal of neuroscience research
    • 2001
    • 56
    Neuronal Pyruvate Carboxylation Supports Formation of Transmitter Glutamate
    • 102
    • PDF
    Selective inhibition of glial cell metabolism in vivo by fluorocitrate
    • 200